11/29/2023 0 Comments Horizon therapeutics gaithersburg md![]() ^ Vanessa Houlder Vincent Boland James Politi (29 April 2014).Bloomberg Special Reports: Corporate Tax Inversions ^ a b "SEC Form 10-K: Horion Pharma public limited company".^ "Amgen to buy Horizon Therapeutics in $26.4 billion deal".^ "Horizon Therapeutics Public Ltd Co 2021 Annual Report (Form 10-K)".^ "US Biopharma Firm Amgen To Acquire Horizon Therapeutics For $28 Bn".Outside the United States, Rayos is also known as Lodotra. The company's lead product base includes Krystexxa, Duexis and Rayos. Horizon's portfolio includes Tepezza ( teprotumumab), Krystexxa ( pegloticase), Actimmune ( interferon gamma), Duexis (ibuprofen + famotidine), Pennsaid (diclofenac, 2% topical), Rayos/Lodotra ( prednisone), Vimovo ( naproxen/ esomeprazole magnesium), Buphenyl ( sodium phenylbutyrate), Procysbi ( cysteamine bitartrate), and Ravicti ( glycerol phenylbutyrate). ![]() Horizon's drug portfolio is focused on treatments for thyroid eye disease (TED), gout, rare diseases, and inflammatory diseases. It is also expanding its development and manufacturing facility in Waterford (Ireland) for the production of rare disease biologics and drugs still in development. In early 2022, the company signed a lease on a large research and development facility in Rockville, Maryland. In July 2015, the Wall Street Journal noted that Horizon were using their lower Irish corporate tax rate to acquire further U.S.–based life sciences firms (i.e. While Horizon's main operations and sales remained in the U.S., Horizon moved their "legal" headquarters to Ireland to avoid U.S. In March 2014, the company executed a corporate tax inversion to Ireland by acquiring Irish–based Vidara Therapeutics International for $660 million. In 2016, the company became a member of the Pharmaceutical Research and Manufacturers of America (PhRMA). The program is planned to promote communications between physicians and patients about NSAIDs and gastrointestinal ulcers. The company has cooperated with American Gastroenterological Association (AGA) Institute to launch a program named "Connect to Protect" which aims to help physicians and patients better understand non-steroidal anti-inflammatory drug (NSAID) risks. Horizon Therapeutics sales by region (2017) Region In May 2023, the Federal Trade Commission said it would sue to block the deal in an attempt to control drug prices. The company was reportedly the center of a bidding war between Amgen, Johnson & Johnson and Sanofi. In December 2022, the company announced it would be acquired by Amgen for $27.8 billion ($116.50 in cash for each Horizon share, a 20% premium). In February 2021, the business announced it would acquire Viela Bio Inc for around $3 billion ($53 per share). Horizon believed it could reach $1 billion peak sales in the US alone. In January 2020 – after showing very strong PhIII data – it was approved for the treatment of thyroid eye disease (TED), a rare vision-threatening disease that previously had no FDA-approved treatment options. On May 2, 2019, shareholders of the company approved the change of the company's name from Horizon Pharma plc to Horizon Therapeutics plc. In 2017, Horizon announced its intention to acquire River Vision Development Corp for $145 million and to continue the development of teprotumumab. In September 2016, the company announced the acquisition of Raptor Pharmaceutical for $800 million, adding Procysbi and Quinsair to its rare drug portfolio. In December, the company acquired Crealta Holdings for $510 million. In March 2015, the company acquired Hyperion Therapeutics for $1.1 billion, increasing Horizon's orphan disease drug portfolio. ![]() In October 2014, the company acquired the US sales and marketing rights to the osteoarthritis drug Pennsaid from Nuvo Research for $45 million. In 2014, Horizon executed a tax inversion to move its legal headquarters to Ireland to avail itself of Ireland's low tax rates and beneficial corporate tax system. Horizon primarily markets products in the United States, which represented 97% of Horizon's 2019 worldwide sales. Horizon Therapeutics is a biopharmaceutical company focused on researching, developing, and commercializing medicines that address critical needs for people impacted by rare and rheumatic diseases.
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11/29/2023 0 Comments Qwest dex white pages address![]() In November 2002 Dex Media acquired Dex Media East, the directory business for the states of Colorado, Iowa, Minnesota, Nebraska, New Mexico (including El Paso, Texas), North Dakota, and South Dakota. Advertising income from the Yellow Pages offset lower utility rates for telephone customers, and the sale of the directories raised issues of potential rate increases. Qwest formed Dex Media East LLC and Dex Media West LLC to divide the directory operations according to states that demanded approval of the sale. The leveraged buyout occurred in two transactions. Each company planned to invest $750 million of equity toward the acquisition and to fund the balance through bank debt and the sale of high-yield (junk) bonds. The Carlyle Group, a global private equity company with more than $13.5 billion under management, and Welsh, Carson, Anderson & Stowe, a private equity firm with more than $12 billion under management, owned Dex Media, established for the purpose of acquiring Qwest Dex. In August 2002, Qwest accepted the $7.05 billion bid from Dex Media, though the purchase price was considered low, at only 7.8 times EBITDA, compared with similar transactions in the directories industry. Qwest received several bids from equity investment groups, but questions about Qwest's accounting practices dissuaded several of the interested parties. Qwest Dex generated approximately $1.6 billion in revenue in 2001 and Qwest expected to gain up to $10 billion from the sale. Qwest Communications decided to sell its directory businesses to offset rising debt and losses. ![]() When US West and Qwest Communications International merged in 2000, the directory business was renamed once again, to Qwest Dex. In 1996, US West launched a new brand, US West Dex, using a man with a magnifying glass as the identifying Dex character. When Mountain Bell took the name US West, Mountain Bell Yellow Pages became US West Direct. Justice Department divided AT&T into seven Regional Bell Operating Companies in 1984. A century later, as part of AT&T, the company became Mountain Bell Yellow Pages when the U.S. originated as a regional publisher of the Yellow Pages, with operations beginning in Cheyenne, Wyoming, in 1881. Forming the Company in 2002 to Acquire Former AT&T Directory Publisherĭex Media, Inc. In addition to providing search capacity for the content of business advertisements, accesses more than 15 million basic business listings and 200 million residential listings nationwide. Dex publishes CD-ROM directories and its Internet Yellow Pages directory is available at. Dex publishes bilingual, English-Spanish directories for more than 20 markets. Available in major metropolitan cities, On-the-Go directories feature maps, shopping and entertainment guides, as well as telephone and address information for central city businesses. In addition to the standard directories, Dex publishes an On-the-Go directory, a nine-inch by six-inch directory designed to be kept in automobiles. Independent directories, in markets not served by Qwest, are published and distributed in El Paso, Texas, and Lincoln, Nebraska. ![]() Although the directories are distributed for free, income is derived from more than 400,000 local businesses and 4,000 national advertising accounts. Dex distributes the directories in 14 states: Arizona, Colorado, Idaho, Iowa, Minnesota, Montana, Nebraska, New Mexico, North Dakota, Oregon, South Dakota, Utah, Washington, and Wyoming. is the official publisher of telephone directory white pages and yellow pages for Qwest Communications. Public Company Incorporated: 2002 Employees: 3,000 Sales: $1.63 billion (2003, includes West Predecessor revenue) Stock Exchanges: New York Ticker Symbol: DEX NAIC: 511140 Directory and Mailing List Publishersĭex Media, Inc. 198 Inverness Drive West Englewood, Colorado 80112 U.S.A. 11/29/2023 0 Comments Adobe premiere pro for studentsSelecting a region changes the language and/or content on. Void where prohibited, taxed or restricted by law. Premiere Pro Discount Price for Students and Teachers If you want to use Premiere Pro for educational purposes as a teacher or a student, you will love to hear Adobe has a special discount for you: Creative Cloud All Apps plan at a cut-price. This pricing is subject to change without notice. Offer may not be assigned, exchanged, sold, transferred, or combined with any other discount or offer, or redeemed for cash or other goods and services. This pricing is limited to one (1) purchase of one (1) Creative Cloud annual membership per customer. This pricing is not available to OEM, commercial or volume licensing customers. This pricing is available for first time membership only and limited to eligible education customers who purchase directly from the Adobe Store or by calling Adobe Sales. At the end of your offer term, your subscription will be automatically billed at the standard subscription rate, currently at US$ 377.87/yr (plus applicable taxes), unless you elect to change or cancel your subscription. Pay US1999 /mo the first year and US2999 /mo after that. One Year Prepaid Creative Cloud Introductory PricingĮligible students 13 and older and teachers can purchase an annual membership to Adobe® Creative Cloud™ for a reduced price of US$ 251.87 for the first year. Students and Teachers get Acrobat Pro as well 20+ apps including Photoshop, Illustrator, Premiere Pro, and InDesign (a 600 value). Void where prohibited, taxed or restricted by law. This pricing is valid for purchases of an annual plan, which requires a 12-month contract. At the end of your offer term, your subscription will be automatically billed at the standard subscription rate, currently at US$ 31.49/mo (plus applicable taxes), unless you elect to change or cancel your subscription. ![]() Both will auto-renew by default, but you can cancel at any. Amazon is currently the only place in the US to get an annual subscription it’s 239.88 before discounts. You can also find the 12-month Student and Teacher plan on Amazon, where it’s usually below full price at £190.55. US$ 20.99/month Creative Cloud Introductory PricingĮligible students 13 and older and teachers can purchase an annual membership to Adobe® Creative Cloud™ for a reduced price of US$ 20.99/mo for the first year. How to get the Adobe CC student discount from Amazon. Introductory Pricing Terms and Conditions 11/29/2023 0 Comments Best kodi addon for adults![]() You will receive a notification when the repo installs successfully. ![]()
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11/28/2023 0 Comments Buick encore gx vs chevy trailblazer![]() Each trim will offer some degree of interior differentiation like stitching, color schemes and added features. Inside, the Trailblazer has an interior that takes its keys from the adventure-oriented exterior. The instruments and controls are well-presented, and the mid-dash info screen is nicely integrated into the dash. In ACTIV trim the Chevy Trailblazer interior has an upscale look. The Hankook Sport Terrain 17-inch tires feature an aggressive shoulder design and an all-season tread pattern. The off-highway ACTIV Trailblazer ACTIV is equipped with unique tires and revised shock tuning to enhance vehicle performance and ride comfort when traveling on gravel roads. The RS features a performance-inspired mesh grille with black Chevy bowtie and unique front splitter elements, but no mention of performance upgrades. It will offer several variants, including an off-road-oriented ACTIV trim and a street-oriented RS, both with standard two-tone roofs. Personalization is a second area that will set Trailblazer apart from Encore GX. ![]() Slotting between the Chevy Trax subcompact and the Chevy Equinox compact crossover SUVs, the Trailblazer channels an exterior look that was set by the recently introduced Chevrolet Blazer, yet another entry in the crossover sweepstakes. In contrast to the Encore’s handsome but understated exterior look, the Chevrolet Trailblazer is far more expressive and off-road-oriented in its exterior design. Bold and off-road-ready are the exterior visuals that distinguish the 2021 Chevrolet Trailblazer. 11/28/2023 0 Comments Best python code formatterOr install the pluging smbl64/vim-black-macchiato: vim-black-macchiato. To format a range of select lines run the vim command: :<,>python -m macchiato.Install black-macchiato by running the shell command: pip install black-macchiato. This setting can be set for all languages or by a specific language. For range formatting you may have a look at black-macchiato. To ensure that this extension is used over other extensions you may have installed, be sure to set it as the default formatter in your VS Code settings. Visual Studio Code Market Place: Prettier - Code formatterĬan also be installed in VS Code: Launch VS Code Quick Open (Ctrl+P), paste the following command, and press enter. It enforces a consistent style by parsing your code and re-printing it with its own rules that take the maximum line length into account, wrapping code when necessary. Search for black and select black from the dropdown called Python>Formatting:Provider. Enable the option Python>Linting:Flake8 Enabled. To set them up: Press ctrl+, to fire up the settings panel. To do so, click the Configure button: Then choose Prettier - Code Formatter. Luckily VS Code comes with both flake8 and black formatter lurking in the settings. Download JSON, once its created or modified. parseJSON and JSON.stringify to beautify JSON easy for a human to read and analyze. Use Auto switch to turn auto update on or off for beautification. This JSON online formatter can also work as JSON Lint. You may then be prompted to choose which format to use. This can be used as notepad++ / Sublime / VSCode alternative of JSON beautification. In the command palette, search for format and then choose Format Document. Prettier is an opinionated code formatter. To open the command palette, you can use COMMAND + SHIFT + P on macOS or CTRL + SHIFT + P on Windows. ![]() ![]() Prettier Formatter for Visual Studio Code ![]() They help learners to perform mental math more quickly and accurately. With these numbers, students can gain an intuitive understanding of numerical values and calculations. ![]() Their importance lies in their ability to simplify complex mathematical operations and estimations. Understanding and using benchmark numbers is crucial for young learners. This term can also apply to fractions like 1/2, 1/4, or 3/4, which are often considered as benchmarks in fraction computations. They are easy to work with and are therefore often used as ‘benchmarks’ when estimating or comparing numbers. They are typically numbers that are multiples of 5 or 10, or decimals like 0.5 or 0.25. The term “benchmark numbers” refers to numbers that serve as a point of reference or standard in the field of mathematics. The reason these numbers are chosen is because they allow for easier calculations and estimations, particularly for young learners. In a majority of cases, these are numbers that end in zeroes or fives, such as 10, 50, 100, or even 0.5. They’re particularly significant in the realm of elementary school mathematics. And, of course, we won’t leave you hanging with questions – our comprehensive FAQ section will ensure all your queries are addressed! What Are Benchmark Numbers?īenchmark numbers, as their name implies, are standard or reference numbers that are easy to comprehend and work with in mathematics. By the end of this article, you will have a deep understanding of what Benchmark Numbers are, their importance, their unique properties, and how to apply them in equations and estimations. These seemingly humble figures, often round numbers or simple fractions and decimals, are the unsung heroes of many mathematical operations, aiding in quick mental calculations, simplifying complex numerical tasks, and acting as the stepping stone to more advanced concepts.Īt Brighterly, we are passionate about making math accessible and enjoyable to children, and our post on Benchmark Numbers epitomizes this mission. Welcome to another insightful post brought to you by the dedicated team at Brighterly, the platform that’s lighting up the world of math for children! Today, we dive deep into a fundamental concept that’s often overlooked, yet integral in every child’s journey to mathematical mastery – Benchmark Numbers. 11/28/2023 0 Comments Mc periodic table![]() At the end of the exclusivity period, the buyer`s license will continue as before, with all of the same rights, except for the right of exclusivity, and the image will again be added to the available library of media on and again be made available to all users for purchase. ![]() The print run for both licenses is unlimited and continues after the exclusivity expired. Similarly, SR-E元 will grant an exclusive right to use the image for three years. SR-EL1 will grant an exclusive right to use the media for one year. The length of time for the exclusivity period depends on which license is selected. ![]() The Contributor acknowledges and agrees to provide the buyer with the exclusive right to use the file retrieved using the SR-EL1 or SR-E元 licenses, for the duration of the selected exclusivity period. The Contributor will be required to disable the file permanently from all other places where he or she may sell it, as soon as possible after the sale occured, but no longer than 72 hours. ĭreamstime will disable the image immediately after the buyer acquired this license. The buyer can use the media exclusively (exclusivity applies from the moment that the file was downloaded using this license) during the time period selected, and include it in any type of design with just a few restrictions: sensitive subjects may still apply and the buyer may not claim that the file was created by him nor resell it as his work. This license represents an exclusive right to use the downloaded media, but such exclusivity will only last for a limited period of time. Physical Items for Resale/Distribution: includes the right to use the photos or stills comprising media for T-shirts, postcards, greeting cards, mugs, mousepads, posters, calendars, framed artwork that is to be sold to other customers for an unlimited number of copies (applies as a total of each type of usage). Note that the other restrictions still apply. This is an additional license to the rights included within the regular Royalty-Free license. Maximum number of electronic items is unlimited (applies as a total of each type of usage). The number of copies allowed is unlimited for each designer/employee.Įlectronic Items for Resale/Distribution: this license includes the right to use the media in webtemplates that are sold to more customers, screensavers, e-cards, powerpoint presentations or as wallpapers on cell phones. The U-EL license is applied only for the staff of the organization that holds the account. It is an additional license to the usage included within the regular Royalty-Free / Editorial license that awards rights for a single person within the same company. This license extends our regular Royalty Free / Editorial license to an unlimited number of seats within the same organization. 11/28/2023 0 Comments Changing battery on quip toothbrushAn electric toothbrush typically uses two AA batteries, so the average lifespan of an electric toothbrush is 4,000mAh. The average lifespan of a AA battery is about 2,000mAh. How long do batteries last in electric toothbrush? How Long Do Batteries Last in Electric Toothbrush? Finally, dispose of the old battery properly. Second, follow the manufacturer’s instructions carefully when replacing the battery. ![]() First, make sure to purchase the correct size and type of battery for your specific model of toothbrush. There are a few things to keep in mind when replacing the battery in an electric toothbrush. Yes, electric toothbrush batteries can be replaced. Screw the back of the toothbrush on tightly to secure the new battery in place Can Electric Toothbrush Batteries Be Replaced?.Insert a new battery into the compartment, making sure it is seated correctly.Remove the old battery from the compartment and dispose of it properly.Unscrew the back of the toothbrush to access the battery compartment.Second, be careful not to damage the bristles or other parts of the toothbrush while replacing the batteries.įinally, make sure you properly dispose of the old batteries. First, make sure you have the right type of batteries. There are a few things you need to keep in mind when replacing the battery in your electric toothbrush. ![]() However, if your toothbrush does not have a rechargeable battery, you will need to replace it every few months. Most electric toothbrushes come with a rechargeable battery, so you will not need to replace it very often. Especially because it sends replacement heads and toothpaste every 3 months.If you have an electric toothbrush, it is important to know how to replace the battery. If you are looking for something that is similar to a manual toothbrush, then this is a great option. In Summary:Īs an electric toothbrush, we are not recommending it to replace a Sonicare or Oral B. Overall, Benjamin Turnwald Dentistry decided it is basically a fancy regular manual toothbrush. On the other end of the toothbrush head, there is a rubber tongue cleaner, but it doesn’t seem to do much in helping scrape the goo from the top of the tongue. Some people enjoy this and others do not. The bristles are a mix of rubber and standard bristles. In general, the electric toothbrushes on the market vibrate the bristle part as well, the Quip DOES NOT. The vibrating motion only seems to happen in the handle, and not so much in the brush head.Īs dental professionals, we love when the toothbrush head also vibrates because it better stimulates and cleans the gum tissue. They are marketing the Quip as an electric toothbrush, and it does vibrate, but at home when brushing your teeth you still need to use mechanical back and forth strokes to properly remove all the plaque and tartar. (Again, from our own personal experience) It also comes in many colors so you can accessorize the toothbrush to your bathroom wall color. It only costs $25! The subscription is an additional charge (about $10), and arrives every 3 months. It is also battery powered, which means it does not need any charging. It comes with a very slim holder that is adhesive and can hang on the wall or bathroom mirror and it isn’t very cumberson. What is also nice about the Quip is the design of how it is stored in the bathroom. The toothpaste is also fluoride based, and does not have a powerful mint flavor. ![]() Something similar to Amazon’s “subscribe and save.” We love this as a dental professional since it is hard in our busy lives to remember to change our toothbrushes out! The toothbrush heads are delivered to you every 3 months, as well as the toothpaste if you choose this option. What originally drew us to the Quip toothbrush, besides how cool it looked, was its subscription option that will automatically send you toothbrush head replacements and/or toothpaste. Many of our patients have been asking about it, so we thought we would write about it in our blog! Well, the time has come and the newest and hottest electric toothbrush has landed in the stores and it is called Quip. The most stylish toothbrush has arrived! It has been many years since a new electric toothbrush has hit the market. Published NovemLast updated October 3, 2019 |
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